Viroinformatics study: polytope mapping of envelope glycoprotein to tackle HIV-2 infection and develop vaccine candidate

Viol Dhea, Kharisma and Muhammad Hermawan, Widyananda and Arif Nur, Muhammad Ansori and Rasyadan Taufiq, Probojati and Ahmad Affan, Ali Murtadl and Muhammad Badrut, Tamam and Adhityo, Wicaksono and Dora Dayu, Rahma Turista (2021) Viroinformatics study: polytope mapping of envelope glycoprotein to tackle HIV-2 infection and develop vaccine candidate. Genbinesia Journal Biology, 1 (1). pp. 1-9.

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Abstraksi

Abstract Human Immunodeficiency Virus type 2 (HIV-2) has been identified to exhibit an ability to resist antiretroviral administration and many scientists has predicted increases in the pathogenicity of HIV-2. The development of a vaccine against the type 1 virus (HIV-1) infection has reached the phase 3 clinical trial stage, but currently there is no information on the development of a vaccine against HIV-2. Vaccine development to trigger an increase in the coverage of the expansion of protection can be done through B cell polytope. This study aims to provide an important preliminary for the construction of vaccine candidates by identifying the peptides that make up the B cell polytope in the HIV-2 envelope glycoprotein region. The HIV-2 sequence was obtained from the database. The study followed by 3D modelling, prediction of linear B-cell epitope mapping, antigenicity, allergenicity, peptide properties, and immune simulation was carried out via a webserver. The 3D structure of the peptide was displayed through molecular visualization software. The results showed that the 23-mer peptides E1 'HPRYTGVKNIRDITLTEPGRGSD', F1 'NFIENRKGTQHN' 12mer, M1 'YLKDQARLNS' 10-mer, N1 'PWVNDSIQPNWNNMTWQQWEL QVRD' 25-mer, and O1 'KLQNSWNMGVQTO' can be used as a candidate polytope HIV-2 vaccine because it is recognized by B cells is an antigenic peptide with stable molecule, non-allergenic. The peptides trigger proliferation and activation of B cells to produces a humoral response and work as functionally protective antibody for neutralization of HIV-2. Keywords: Acquired immune deficiency syndrome, B-cell, bioinformatics, human immunodeficiency virus, retrovirus

Item Type:	Article
Uncontrolled Keywords:	Acquired immune deficiency syndrome, B-cell, bioinformatics, human immunodeficiency virus, retrovirus
Subjects:	Fakultas Sains, Teknologi dan Pendidikan > S1 Biologi
Divisions:	Fakultas Sains, Teknologi dan Pendidikan
Depositing User:	Admin
Date Deposited:	24 Jun 2022 04:35
Last Modified:	24 Jun 2022 04:35
URI:	http://repository.umla.ac.id/id/eprint/1975

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