Protective Effect of Lemongrass Extract (Cymbopogon nardus) on Spermatozoa Cells of Lead Acetate Induced Mice

Putri Ayu Ika, Setiyowati and Rofiatun, Solekha and Dwi Dianita, Irawan and Reny, Rosalina and Karin Alifia, Rachmadani and Angella Ananda, Saputra (2022) Protective Effect of Lemongrass Extract (Cymbopogon nardus) on Spermatozoa Cells of Lead Acetate Induced Mice. Biomolecular and Health Science Journal, 5 (1). pp. 29-32. ISSN 2620-8636

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Introduction: Male infertility can be caused by many factors. One of which is environmental pollution such as lead acetate. Lead acetate exposure can increase Reactive Oxygen Species (ROS), affecting spermatozoa quality. Natural antioxidants and flavonoid on Lemongrass (C. nardus) have a great potential for protecting the male reproductive system. This study aimed to analyze the effect of giving various dosages of C. nardus extract on the sperm quality of mice. Methods: The Balb/C male mice were divided into five equal groups. The negative control group was injected with 0.01 ml Na-CMC 0.5% within 40 days, and the positive control group was injected with 0.01 ml lead acetate 7 mg/kg BW within 5 days, the treatment groups were injected by 0.01 ml lead acetate 7 mg/kg body weight within 5 days and continuously injected by 0.01 ml of C. nardus extract with various dosage 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW within 35 days. At the end of the experiment, mice were sacrificed, and sperm suspensions were collected from cauda epididymal to measure the morphology, concentration, and motility. Results: The results showed that giving C. nardus extract could repair morphology, concentration, and motility of spermatozoa with significantly different (p<0.05). The 25 mg/kg BW dose has a good protective effect. Conclusion: The C. nardus extract can repair the decreasing sperm quality caused by lead acetate exposure.

Item Type: Article
Uncontrolled Keywords: Lemongrass extract; spermatozoa cells; lead acetate
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
Divisions: Fakultas Ilmu Kesehatan
Fakultas Sains, Teknologi dan Pendidikan
Depositing User: Dosen Putri Ayu Ika Setiyowati
Date Deposited: 29 Jan 2024 01:00
Last Modified: 29 Jan 2024 01:00

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