Vaccine construction for human papillomavirus (HPV) type 16 and 18 infection using in silico approach to combat cervical cancer

Muhammad Alsyifaa, Dharmawan and Arif Nur, Muhammad Ansori and Farida Aryani, Dian and Rasyadan Taufiq, Probojati and Muhammad Badrut, Tamam and Viol Dhea, Kharisma (2021) Vaccine construction for human papillomavirus (HPV) type 16 and 18 infection using in silico approach to combat cervical cancer. Genbinesia Joutnal of Biology, 1 (1). pp. 1-10.

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Abstraksi

Abstract Human papillomavirus (HPV) is a virus that causes infection on the surfaceof the skin and has the potential to cause cervical cancer. This viral infectionis characterized by the growth of warts on the skin in various areas of thebody, such as the arms, legs, mouth, and genital area. Because the virus canendanger health, it is necessary to design an HPV vaccine to overcome thisproblem. In this study, we performed a study characterization of HPV types 16 and 18 sequences to obtain immunogenic epitopes retrieved from theNational Center for Biotechnology Information (NCBI) web server. Then,epitope prediction was performed using the immune epitope database (IEDB) web server and selected to get the best vaccine candidate for HPVtypes 16 and 18. We recommend 16P1 as an epitope-based peptide vaccine candidate for HPV type 16 and 18P4 for type 18. Both vaccine candidatesare antigenic, non-allergenic, and non-toxic. The 16P1 and 18P4 have thelowest global energy values among the other candidates. However, furtherresearch is needed to be able to develop the best vaccine (in vitro and invivo experiments). Keywords: Epitope-based peptide vaccine, human papillomavirus, Immunoinformatics

Item Type: Article
Uncontrolled Keywords: Epitope-based peptide vaccine, human papillomavirus, Immunoinformatics
Subjects: Fakultas Sains, Teknologi dan Pendidikan > S1 Biologi
Divisions: Fakultas Sains, Teknologi dan Pendidikan
Depositing User: Admin
Date Deposited: 24 Jun 2022 04:12
Last Modified: 24 Jun 2022 04:12
URI: http://repository.umla.ac.id/id/eprint/1974

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